Manhattan Melodrama

The friendship between two orphans endures even though they grow up on opposite sides of the law and fall in love with the same woman.

• 
  W.S. Van Dyke

• 
  Clark Gable
  Edward J. 'Blackie' Gallagher
• 
  William Powell
  Jim Wade
• 
  Myrna Loy
  Eleanor Packer
• 
  Leo Carrillo
  Father Joe
• 
  Nat Pendleton
  Spud
• 
  George Sidney
  Poppa Rosen
• 
  Isabel Jewell
  Annabelle
• 
  Muriel Evans
  Tootsie Malone
• 
  Thomas E. Jackson
  Asst. Dist. Atty. Richard Snow
• 
  Isabelle Keith
  Miss Adams
• 
  Noel Madison
  Manny Arnold
• 
  Jimmy Butler
  Jim Wade as a Boy
• 
  Mickey Rooney
  Blackie as a Boy
• 
  Shirley Ross
  Singer in Cotton Club
• 
  Donald Haines
  Young Spud (uncredited)
• 
  Frank Conroy
  Blackie's Defense Attorney (uncredited)
• 
  Leonid Kinskey
  Trotskyite Slapping Poppa Rosen
• 
  Oscar Apfel
  Speaker of Assembly (uncredited)
• 
  William Bailey
  Al Barnes (uncredited)
• 
  Curtis Benton
  Announcer (uncredited)